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To ensure healthy tomato plants, start with disease-resistant varieties and plant them in well-drained soil with plenty of organic matter. Rotate crops annually to prevent soil-borne diseases and pests. Prune the plants to improve air circulation and reduce the risk of fungal infections. Regularly inspect plants for signs of pests or disease and address issues promptly. Consistent watering, especially during dry spells, is crucial for nutrient uptake and overall plant health.